Date of Project
4-19-2024
Document Type
Honors Thesis
School Name
College of Arts and Sciences
Department
Chemistry
Major Advisor
Dr. Amanda Krzysiak
Abstract
Cancer is currently the second leading cause of death in the US. While much progress has been made, there is still a significant need for novel therapies. Chalcones are privileged, natural products that have shown cytotoxic activity and potential as chemotherapeutics in multiple cancerous cell lines. Additionally, bismuth complexes of small organic molecules have been shown to have anti-tumor activity. The anti-proliferative activity of phenylbismuthbis(4-carboxychalcone), a bismuth-coordinated chalcone was assessed in multiple cancer cell lines using MTS assays. The compound demonstrated micromolecular inhibition. Additionally, mechanism of action studies were performed to assess if the anti-proliferative activity seen is due to an induction of apoptosis. Western blotting suggests drug treatment with phenylbismuthbis(4-carboxychalcone) results in the activation of apoptotic cascades.
Recommended Citation
Baker, Megan, "Investigation of the Anticancer Activity of phenylbismuthbis(4-carboxychalcone)" (2024). Undergraduate Theses. 142.
https://scholarworks.bellarmine.edu/ugrad_theses/142