Date of Project

4-27-2018

Document Type

Honors Thesis

School Name

College of Arts and Sciences

Department

Biology

Major Advisor

Amanda Krzysiak

Abstract

Chalcones, a precursor to flavonoids, are chemical compounds found naturally in plants. The chalcones’ structure consists of a ketone bridge attached to two aromatic rings. Varying substituents on the aromatic rings allow for different affects, including anti-cancer properties. As a Michael acceptor, chalcones interact with pathways that cause inhibition of the initiation, promotion, and progression of cancer tumors. We have screened 32 compounds for growth inhibition in lung cells that vary the flexibility and confirmation of the 3 carbon bridge between the two aromatic rings as well as the effects of electronic modifications to the aromatic ring. We have found that constraining the ring has negative effects on biological activity.

Available for download on Sunday, June 28, 2020

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