Date of Project
College of Arts and Sciences
Chalcones, a precursor to flavonoids, are chemical compounds found naturally in plants. The chalcones’ structure consists of a ketone bridge attached to two aromatic rings. Varying substituents on the aromatic rings allow for different affects, including anti-cancer properties. As a Michael acceptor, chalcones interact with pathways that cause inhibition of the initiation, promotion, and progression of cancer tumors. We have screened 32 compounds for growth inhibition in lung cells that vary the flexibility and confirmation of the 3 carbon bridge between the two aromatic rings as well as the effects of electronic modifications to the aromatic ring. We have found that constraining the ring has negative effects on biological activity.
Kuo, Mary Elaine, "A Cytotoxic Evaluation of a Chalcone Derivative Library on A549 Cells" (2018). Undergraduate Theses. 32.
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