Impact of Pulmonary Exposure to Gold Core Silver Nanoparticles of Different Size and Capping Agents on Cardiovascular Injury
Particle and Fibre Toxicology
Donna and Allan Lansing School of Nursing and Health Sciences
Department of Physical Therapy
The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the ability to exacerbate cardiac ischemia reperfusion (I/R) injury. However, the influence of particle size or capping agent remains unclear. In an effort to address these influences we explored response to 2 different size gold core nanosilver particles (AgNP) with two different capping agents at 2 different time points. We hypothesized that a pulmonary exposure to AgNP induces cardiovascular toxicity influenced by inflammation and vascular dysfunction resulting in expansion of cardiac I/R Injury that is sensitive to particle size and the capping agent.
Wingard et al., Christopher, "Impact of Pulmonary Exposure to Gold Core Silver Nanoparticles of Different Size and Capping Agents on Cardiovascular Injury" (2016). Physical Therapy Faculty Publications and Presentations. 5.