Date of Project
4-27-2018
Document Type
Honors Thesis
School Name
College of Arts and Sciences
Department
Biology
Major Advisor
Amanda Krzysiak
Abstract
Chalcones, a precursor to flavonoids, are chemical compounds found naturally in plants. The chalcones’ structure consists of a ketone bridge attached to two aromatic rings. Varying substituents on the aromatic rings allow for different affects, including anti-cancer properties. As a Michael acceptor, chalcones interact with pathways that cause inhibition of the initiation, promotion, and progression of cancer tumors. We have screened 32 compounds for growth inhibition in lung cells that vary the flexibility and confirmation of the 3 carbon bridge between the two aromatic rings as well as the effects of electronic modifications to the aromatic ring. We have found that constraining the ring has negative effects on biological activity.
Recommended Citation
Kuo, Mary Elaine, "A Cytotoxic Evaluation of a Chalcone Derivative Library on A549 Cells" (2018). Undergraduate Theses. 32.
https://scholarworks.bellarmine.edu/ugrad_theses/32
Included in
Alternative and Complementary Medicine Commons, Biochemistry Commons, Circulatory and Respiratory Physiology Commons, Laboratory and Basic Science Research Commons, Medical Biochemistry Commons, Oncology Commons, Organic Chemicals Commons, Other Chemicals and Drugs Commons, Pharmaceutical Preparations Commons, Respiratory Tract Diseases Commons